DNMT1 and glioma: Walsh et al. (2016) pointed that ADAMTS9-AS2 plays a critical role in epigenetic regulation, affecting early stage digit development. Recently, the ADAMTS9-AS2 locus has been revealed as a potential therapeutic target and prognostic marker in gliomas. ADAMTS9-AS2 serves as a tumor suppressor, which is significantly down-regulated in glioma tissues, and its expression is negatively correlated with tumor grade and prognosis. Meanwhile, DNMT1 knockdown remarkably enhances ADAMTS9-AS2 expression, inhibiting cell migration in gliomas (Yao et al., 2014).