MET and central nervous system cancer: Zhen et al. (2016) demonstrated that functioning as a molecular sponge for miR-449b-5p, NEAT1 could up-regulate the expression of c-Met, a direct target of miR-449b-5p, thus promoting glioma oncogenesis. Furthermore, clinical investigations revealed that aberrant NEAT1 expression is negatively associated with clinical outcome in high-grade glioma patients (He C. et al., 2016).