In addition, as the gene enhancer of zeste homolog 2 (EZH2) serves as an oncogene and is required for cancer stem cell maintenance, the inhibition of EZH2 by lncRNAs can effectively promote the therapeutic sensitivity in gliomas (van Vlerken et al., 2013; Yin et al., 2016). The gene discussed is EZH2; the disease is central nervous system cancer.