Baldinu et al. (2007) revealed that the exogenous expression of CASC2a in undifferentiated endometrial cancer cells significantly inhibits the clonal growth. Using a positional candidate approach, 7% CASC2a mutations in tumor DNA from 44 endometrial cancer patients were identified (Baldinu et al., 2004), suggesting that inactivation of CASC2a might probably be due to mechanisms different from genetic alterations. In non-small cell lung cancer (NSCLC) tissues and cell lines, He X. et al. (2016)) reported that CASC2 expression is involved in the development and progression of NSCLC. This evidence concerns the gene CASC2 and neoplasm.