In this regard, recent studies have demonstrated that lncRNAs in gliomas can serve as molecular decoys, which move proteins or RNAs away from a specific location, like a “sponge” to miRNAs (e.g., HOTAIR/miR-326, CASC2/miR-21, XIST/miR-152, and Gas5/miR-222). This evidence concerns the gene HOTAIR and central nervous system cancer.