In addition, there is an estimate of 30 genes directly linked to the pathophysiology of the disease, including TARDBP, FUS, OPTN, VCP, UBQLN2, C9ORF72, PFN1...etc., and over 120 other genes indirectly associated with ALS (Abel et al., 2012). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.