SNCA and Parkinson disease: For instance, α-synuclein misfolds into amyloid fibrils that accumulate in Lewy bodies in the dopamine neurons of PD patients, while in ALS patients TDP-43 or FUS misfold into cytoplasmic aggregates in degenerating motor neurons and glia (Spillantini et al., 1997; Neumann et al., 2006; Chen-Plotkin et al., 2010; Mackenzie et al., 2010; Robberecht and Philips, 2013; Dehay et al., 2015).