ALB and focal segmental glomerulosclerosis: 2010), and although podocyte cell counting was not performed, nephrin and WT1 staining were found to be reduced compared with BTBR lean controls, both at the mRNA and protein expression levels at 24 weeks age. AZD6610 did not seem to improve any of the podocyte markers measured semiquantitatively. Podocyte protective effects and improved renal function have been reported with PPAR agonism in a nondiabetic model of podocyte injury (FSGS) (Yang et al. 2006), but in the current study, insufficient podocyte protection may partly explain the lack of effect on albumin excretion.