Studies on patients with intrahepatic cholestasis or idiopathic cholestasis during pregnancy indicated that polymorphism c.1331 T > C (p.V444A) (SNP rs2287622) in exon 13 of BSEP gene would lead to inhibition of the transportation of bile acid out of the hepatocytes [17, 25, 26]. Here, ABCB11 is linked to intrahepatic cholestasis.