ADIPOQ and hypertensive disorder: Another study in adiponectin deficient mice, in which the animals were subjected to aldosterone-induced hypertension in addition to uninephrectomy, showed that hypoadiponectinaemia exacerbated hypertension-induced DD with increased LV mass, increased E/A ratio, reduced e’ wave and increased E/e’ ratio in the adiponectin deficient mice compared to the wild type [30].