5 Mockenhaupt Mockenhaupt F F Cramer Cramer J J Hamann Hamann L L Stegemann Stegemann Stegemann Toll Like Receptor polymorphisms in African children: Common TLR-4 variants predispose to severe malaria Toll Like Receptor polymorphisms in African children: Common TLR-4 variants predispose to severe malaria Proc Natl Acad Sci USA. The gene discussed is TLR4; the disease is malaria.