GPT and viral infectious disease: Hepatotoxicity could theoretically be a possible adverse effect of an AAV8 vector as it has strong liver tropism [12]; however, AAV viral infection does not elicit any reported adverse responses in animals, and post-injection levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were similar to those of uninjected mice or mice injected with control AAV8 viral particles (AAV-Null) (Fig 1D).