In our model with selected cancer cell lines (MCF-7, HeLa, KTC-1, PC-3, Myc-CaP and HT 1080) and proliferating endothelial cell cultures, nanomolar concentrations of 17AAG, NVP-AUY922, geldanamycin and radicicol yielded only a slight (20–30%) increase in the intracellular levels of Hsp27 and Hsp40 but no significant changes in the expression of Hsp110, Hsp90 and Hsp60 (data not shown). The gene discussed is HSPH1; the disease is cancer.