TACR1 and depressive disorder: Several studies have reported the contribution of TACR1 to affective, anxiety and motivated disorders such as addictive behavior,74 bipolar disorder,75, 76, 77 attention deficit hyperactivity disorder,75, 78 depression,79, 80 fear81, 82 and anxiety.73, 81, 83, 84, 85 AN presents as a motivated disorder with anxiety3 induced by palatable food and is frequently comorbid with mood symptoms,3 especially while the patient is underweight.