On the basis of the results of the pathway analysis, we sought to functionally investigate the modulation of the four genes assigned to the top-enriched canonical pathway (GR signaling): MED1, GTF2A1, HSPA1L and TAF15. Expression of these four genes was reduced in PBMCs from patients with BD and unaffected offspring compared to controls (Figure 1d). The gene discussed is NR3C1; the disease is Behcet disease.