Our database and literature mining showed that differential gene expression in peripheral blood cells from BD patients had been previously reported for some of the risk genes identified, including ZNF641 and ZNF234, members of the zinc-finger family of genes, of which ZNF804A has been associated with BD and psychosis in genome-wide association study.32, 33 Although most of the risk genes had not been previously shown to directly confer risk for BD, many of them are within pathways previously implicated in BD (Figure 2). This evidence concerns the gene ZNF234 and Behcet disease.