On the basis of the results of the pathway analysis, we sought to functionally investigate the modulation of the four genes assigned to the top-enriched canonical pathway (GR signaling): MED1, GTF2A1, HSPA1L and TAF15. Expression of these four genes was reduced in PBMCs from patients with BD and unaffected offspring compared to controls (Figure 1d). This evidence concerns the gene HSPA1L and Behcet disease.