Interestingly, top-ranked canonical pathways include Fcγ receptor-mediated phagocytosis in macrophages and monocytes, PTEN signaling, Cdc42 signaling, Tec kinase signaling and interleukin-15 production, which have all been previously directly or indirectly associated with BD pathophysiology or treatment.23, 24, 25. Here, PTEN is linked to Behcet disease.