Alternatively, in some significantly fibrotic regions of LC patients, NKp46+ NK cells were found to be distributed separately with α-SMA+ HSCs: few NKp46+ cells were observed in α-SMAbright areas; by contrast, in α-SMAdim regions, more NKp46+ NK cells were detected in the livers of LC patients. The gene discussed is ACTA1; the disease is laryngotracheoesophageal cleft.