IFNG and laryngotracheoesophageal cleft: As shown in Fig. 4c, purified NK cells displayed similar levels of production of CD107a and IFN-γ when incubated with medium, TGF-β, plasma from LC patients or LX-2 cells-derived supernatants; however, blockade of TGF-β using anti-TGF-β antibodies significantly enhanced the production of CD107a and IFN-γ by NK cells when incubated with LC plasma and supernatants.