Thus, with the aim of elucidating the effects of hepatic Plpp3 deletion on circulating lipid levels, which might affect atherosclerosis development, a lipidomic analysis was conducted on Plpp3f/f apoE−/− Alb-Cre− and Plpp3f/f apoE−/− Alb-Cre+ mouse plasma. This evidence concerns the gene APOE and atherosclerosis.