APOE and atherosclerosis: En-face analysis of the entire aorta of the Western diet-fed mice showed a dramatic increase in aortic atherosclerosis in Plpp3f/f apoE−/− Alb-Cre+ mice, specifically in the aortic arch and the thoracic segment, as compared with Plpp3f/f apoE−/− Alb-Cre− mice (Fig. 4A,B).