To investigate the role played by hepatic LPP3 during atherosclerosis development, Plpp3f/f apoE−/− Alb-Cre− and Plpp3f/f apoE−/− Alb-Cre+ mice were fed, after weaning, a chow diet for 32 weeks or a Western diet for 12 weeks. Here, ALB is linked to atherosclerosis.