APOE and atherosclerosis: In contrast, when challenged with a Western diet, Plpp3f/f apoE−/− Alb-Cre+ mice showed a 35% increase in atherosclerosis development, as compared with Plpp3f/f apoE−/− Alb-Cre- mice (p = 0.031) (Fig. 2B,D,F and Table 1).