Interestingly enough, a very recent report49 identified the 12(S)-Hydroxyeicosatetraenoic acid (12-HETE) receptor (GPR31, 12-HETER) in prostate cancer tissue, further linking arachidonic acid metabolites as novel potent modulators of prostate growth and providing further elements for novel therapeutic approaches in this disease. Here, GPR31 is linked to Familial prostate cancer.