LTB4R and Sepsis: Furthermore, serum LTB4 concentrations are elevated during sepsis17, 18, 19 and may contribute to sepsis-induced injuries to various organs, as well as septic shock and septic death, because these processes can be attenuated by a BLT1 antagonist20, 21, 22, 23.Notably, elevated LTB4 contributes to vascular endothelial disorders during sepsis18, 19.