AKT1 and cancer: CX-4945, also known as Silmitasertib, is a highly specific, ATP-competitive inhibitor of CK2 that induces cytotoxicity and apoptosis by suppressing the activation of the CK2-mediated PI3K/Akt/mTOR signaling pathways and is currently being evaluated in clinical trials for the treatment of many types of cancer, including hematological malignancies and bile duct cancers44.