In the “rRNA metabolic process” module, NCL and NOLC1 have been reported as prognostic and diagnostic markers in lung cancer25; UTP18 can promote tumorigenesis in many human cancers, and the correlation between UTP18 overexpression and decreased survival of neuroblastoma and breast cancer patients suggests its potential utility as a prognostic marker26. The gene discussed is NUCLEOLIN; the disease is breast carcinoma.