CX-4945, also known as Silmitasertib, is a highly specific, ATP-competitive inhibitor of CK2 that induces cytotoxicity and apoptosis by suppressing the activation of the CK2-mediated PI3K/Akt/mTOR signaling pathways and is currently being evaluated in clinical trials for the treatment of many types of cancer, including hematological malignancies and bile duct cancers44. This evidence concerns the gene MTOR and hematologic disorder.