Several chemokine-chemokine receptor pairs have been proposed to be responsible for recruiting Tregs to tumors including chemokine receptors CCR4, CCR10, CCR8 or CXCR3 expressed on infiltrating Tregs, responding to CCL22, CCL28, CCL1 or CXCL9-11 in the tumor microenvironment, respectively10,11,12. This evidence concerns the gene CCR8 and neoplasm.