IL22 and autoimmune disease: Characterized by expression of aryl hydrocarbon receptor as key transcription factor and production of inflammatory cytokines IL-22 and TNF-α, TH22 cells play a substantial role in inflammatory and autoimmune disorders such as psoriasis, atopic dermatitis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 and 2 diabetes [29].