Numerous studies have indicated that various surface markers (Table 1) such as CD133, CD90, ALDH, and EpCAM, are used to identify and isolate CSCs in cancer types, and that their expression levels are different from those of other bulk tumor cells (Zhu et al., 2015; Deng et al., 2015; Pan et al., 2015). This evidence concerns the gene LDHA and cancer.