EpCAM plays an important role in self-renewal, proliferation, and differentiation of CSCs; moreover, its high-level expression can increase tumorigenesis in breast, colon, and head and neck squamous cell carcinoma (Van der Gun et al., 2010; Visvader and Lindeman, 2008) as well as migration and invasion of cancers, such as breast cancer and retinoblastoma (Mitra et al., 2010; Osta et al., 2004). Here, EPCAM is linked to cancer.