ADCs were significantly associated with VEGF protein expression in epithelial cells (WLsp-ROI r = 0.540, P = 0.001; S-ROI r = 0.552 P = 0.001) and inversely associated with Ki-67 protein expression in the nucleus (WLsp-ROI r = -0.540, P = 0.001; S-ROI r = -0.507, P = 0.003; Fig. 5), but not with other histopathologically measured variables in primary tumours. The gene discussed is MKI67; the disease is neoplasm.