Clinicians’ understanding of and ability to achieve wound healing has increased significantly over the past few years, particularly as a result of advances in molecular biology such as the use of growth factors, the ability to grow cells in vitro and the development of bioengineered tissue.41-43 Knowledge of scarring has also increased fundamentally.44-47 some promising results have been obtained using epidermal growth factor.48 and keratinocyte growth factor-249 for venous ulcers, and fibroblast growth factor50 and platelet-derived growth factor (PDGF) for pressure ulcers.51,52. The gene discussed is EGF; the disease is varicose ulcer.