The detected total protein level alteration along the adenoma-carcinoma transition of the analyzed colorectal tissue samples was fundamentally constituted by the increased epithelial cyclin D1 expression (adenoma ΣQ score: 96.25 ± 18.75 and CRC ΣQ score: 147.00 ± 48.94. Here, CCND1 is linked to colorectal carcinoma.