A novel model of tumorigenesis was proposed by Bartkova et al. (2005) and Gorgoulis et al. (2005), suggesting that DNA replication stress enhance DSBs formation, leading to genomic instability and selective pressure for p53 mutations, abrogating the tumor suppressing actions of p53 (Halazonetis et al., 2008). Here, TP53 is linked to neoplasm.