Upregulation of TNF family members involved in T and B lymphocytes activation including APRIL/TNFSF13, BAFF/TNFSF13B, sCD30/TNFRSF8 were also observed in BD patients underling a potential role of these cytokines in the immune response (23, 24). This evidence concerns the gene TNFRSF8 and Behcet disease.