Interestingly, Heller et al. (166) suggested that a delayed/reduced presence of EBNA1-specific antibody, as well as CD4+ T cells, observed in infectious mononucleosis patients (169, 170) can be one of the possible explanations for the increased risk to develop Hodgkin lymphoma after symptomatic acquisition of EBV infection. Here, CD4 is linked to infectious mononucleosis.