Significantly, there was an increase of classically activated microglia (CD45medCD11b+CD11c+) in the CNS of BALB/c mice 25 days after MCMV infection compared to MOG35–55-immunized mice without previous infection that had mostly alternatively activated microglia (CD45medCD11b+CD206+) (Figure 5F). This evidence concerns the gene ITGAX and infection.