Unlike previous reports, in this work the researchers could not detect elevated MICA mRNA levels in kidney biopsies derived from patients undergoing acute rejection (AR) or chronic allograft nephropathy. In contrast, they observed a strong NKG2D mRNA induction during renal-allograft rejection, which was verified by immunohistology in kidney biopsies. The gene discussed is MICA; the disease is Crouzon syndrome-acanthosis nigricans syndrome.