Unlike previous reports, in this paper, the researchers could not detect elevated MICA mRNA levels in kidney biopsies derived from patients undergoing AR or chronic allograft nephropathy. In contrast, they observed a strong mRNA induction of NKG2D during renal-allograft rejection, which could be verified by immunohistology in kidney biopsies. The gene discussed is MICA; the disease is Crouzon syndrome-acanthosis nigricans syndrome.