In fact, in late melanoma stage, NF-κB is up-regulated and inhibits cell apoptosis by enhancing the expression of several anti-apoptotic genes such as XIAP (Deveraux et al., 1998), c-FLIP (Micheau et al., 2001), and BclxL genes (Ravi et al., 2001). The gene discussed is CFLAR; the disease is melanoma.