ADA also inhibited the proliferation of all the other human melanoma cell lines employed in this study, namely SK-Mel-5, SK-Mel-28, WM983A, and PES43 cell lines, all carrying the BRAFv600E mutation and the WM3060 cell line wild type for BRAF, without affecting NHEM proliferation (Table 1). This evidence concerns the gene ADA and melanoma.