CELSR3 and myeloid sarcoma: As a consequence of the loss of the myelin sheath in experimental demyelination models or in MS, nodal regions are characterized by a large redistribution or de novo expression of anchoring proteins and voltage-gated ion channels (Rasband et al., 1998; Arroyo et al., 2002; Craner et al., 2004; Black et al., 2006; Hamada and Kole, 2015).