RGC degeneration models mimic the diseases of glaucoma, optic neuritis, traumatic optic neuropathy injury, and etc. HIF-1α was detected in the retina and optic nerve head of human glaucomatous eyes compared with the control eyes, and its expression was closely concordant with the location of visual field defects recorded in these eyes (Tezel and Wax, 2004). Here, HIF1A is linked to glaucoma.