Indeed, ESRP1-CD44v-xCT axis has been demonstrated to enhance the efficiency of breast cancer cells to form metastatic foci in the lungs; CD44v-positive 4T1 murine breast cancer cells are significantly able to metastasize to the lungs as compared with CD44v-negative 4T1 cells [10]. Here, ESRP1 is linked to breast carcinoma.