ANK3 and autism: Forexample, in the bipolar cohort four MBS variants across six probands were identifiedin a leading candidate gene, ANK3. 56 In ASD cohorts, MBS variants were identified inBRD12 andCHD2,9 both of which havebeen previously linked to autism via identification of putatively pathogenic denovo protein-coding mutations and copy number variants.62, 63, 64 Indeed, taken together, these findings argue forexamination of the 3′UTR regions of candidate genes across a range of disorderswithin existing NGS data sets.