Similarly, clinical trials with GABA-B receptor agonists, such as baclofen or γ-hydroxybutyric acid, have given no unanimous picture for antipsychotic effects of these drugs.57, 58 Indeed, the most common adverse effects observed of vigabatrin is behavioral disturbances, ranging from irritability and confusion to psychotic reactions.59 Thus, the many experimental and post-mortem studies, suggesting a role of GABA in the pathophysiology of schizophrenia is not supported by the clinical experience of medication with GABA receptor agonists. The gene discussed is GABBR1; the disease is schizophrenia.