Specifically, immunofluorescence analysis of collagen IV (Fig. 2A), fibronectin (Fig. 2B), and laminin α5 (Fig. 2C) and α4 chains (Fig. 2D) in the BM around tumour blood vessels, revealed a ‘shorelining’ pattern of BM components (DiPersio et al., 1997) in pdgfrβcre+;α6fl/fl mice. The gene discussed is FN1; the disease is neoplasm.