TGFB1 and neoplasm: The complexities of stromal–epithelial interactions involving TGF-β signaling manifest itself as a tumor suppressor in tumorigenesis, yet demonstrate tumor promoting activity in metastatic progression (Bhowmick et al. 2003, 2004, Taylor et al. 2011, Lebrun 2012, Smith & Kang 2013, Neuzillet et al. 2015).