CYP2D6 and malaria: CYP2D6-related differences in PQ transmission blocking efficacy would be particularly relevant in malaria elimination settings, where mass drug administration are used to accelerate transmission interruption: CYP2D6 poor metabolizers might remain infectious for longer periods of time after PQ administration compared to individuals with other CYP2D6 genotypes and could represent a source of residual malaria transmission in these areas, depending on the frequency of alleles linked to this phenotype in the population.