CASP3 and systemic lupus erythematosus: As expected, the levels of both 7-AAD- and active caspase-3-positive cells were increased in MAIT cells in patients with SLE (median 2.79 [IQR 1.31–3.89], 2.31 [IQR 2.11–3.94], respectively) (Fig. 2a) compared with the HCs (median 0.55 [IQR 0.24–1.53]; 0.73 [0.08–1.30], respectively) (Fig. 2a), indicating that cell death is enhanced in MAIT cells in lupus.