CYP51A1 and congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency: The pathogenic mechanisms of PORD-associated skeletal deformities may be associated with lanosterol 14α demethylase (CYP51A1) which involved in cholesterol biosynthesis [17] and retinoic acid which metabolized by microsomal CYP26 proteins [18].