We have shown that Meso-H.28z T cells have a better tumor-eradication capacity than Meso.28z T cells in tumor-bearing mice, suggesting that the mesothelin epitope recognized by the scFv may be membrane-proximal, or that there exist steric inhibitory effects between scFv and its epitope, like in SM3 mAb (a MUC1-specific mAb) [20]. Here, MUC1 is linked to neoplasm.