CDH1, which encodes epithelial cadherin (E-cadherin), an epithelial specific protein controlling cell-cell adhesion [21], was upregulated by 28.5 fold, whereas CAV2 which encodes caveolin-2, a potent tumor suppressor controlling lipid metabolism, growth, and apoptosis [22], was upregulated by 9 fold in shMSLN cells. Here, CAV2 is linked to neoplasm.