Koo et al. developed a prognostic model using 2805 patients with metastatic or recurrent GC undergoing chemotherapy, and found that Eastern Cooperative Oncology Group (ECOG) performance status ≥2, no gastrectomy, presence of peritoneal, bone, or lung metastases, high levels of serum alkaline phosphatase (>120 U/L) and total bilirubin (>1.2 mg/dL), and a low serum albumin level (<3.3 g/dL) were poor prognostic factors [14]. The gene discussed is ALB; the disease is gastric cancer.