Adding to the controversy around FTO, a recent report [9] clearly showed that the obesity associated SNPs in FTO function as a long-range promoter for the downstream IRX3 (Iroquois Homeobox 3) gene, but not for FTO. Despite this, several reports suggest that FTO has a direct role in regulation of food intake and preference [10], as well as fat development, maintenance and metabolism [11–14]. This evidence concerns the gene IRX3 and obesity due to melanocortin 4 receptor deficiency.