For example, the expression of cir-ITCH (hsa_circ_0001141, hsa_circ_001763) has been shown to be significantly downregulated in squamous cell carcinoma of the esophagus as well as colorectal cancer tumors, the expression of hsa_circ_002059 has been shown to be significantly downregulated in gastric malignancies, and the expression of hsa_circ_0001649 has been shown to be significantly downregulated in hepatocellular carcinoma (HCC) tumors [9]. This evidence concerns the gene ITCH and hepatocellular carcinoma.