EGFR and glioblastoma: Again, it has been recently reported that, in PDGFR signaling (in Reactome), transcriptional de-repression of PDGFR-β contributed to compensating for the effects of EGFR-TKIs in EGFR-mutant glioblastoma via an mTORC1- and extracellular signal regulated kinase-dependent mechanism [21].