We found literature evidence (Fig 6C) supporting a role in breast cancer metastasis and/or in developing acquired resistance to EGFR-TKIs for the SMAD4 − TGFBR2 − RPS6KA2 (Type-II) V-structure in SKBR3, and SMAD4 − LEF1 − CCND2 (Type-II) and PTEN − TP53 − DDB2 (Type-III) V-structures in BT474 cell lines, respectively. Here, SMAD4 is linked to breast cancer.