It has been reported that the VEGF/VEGFR-2 feed-forward loop increases VEGF secretion in lung cancer via mTOR-dependent regulation that is required for the activation of downstream signaling [54], and the over-expression of VEGFR-1 reduces EGFR-TKIs sensitivity in different human cancer cells [3, 55]. The gene discussed is VEGFA; the disease is lung carcinoma.