IL-6 and IL-8 are inflammatory cytokines that exert tumor-promoting activity.22, 23, 24 We confirmed the results of our gene expression array analysis and noted that, similar to those results, SHMT1 loss resulted in significant downregulation of IL-6 and IL-8 mRNA in PEO4 cells (Figure 5a). The gene discussed is CXCL8; the disease is neoplasm.