CXCL8 and ovarian carcinoma: To determine if SHMT1 loss-mediated downregulation of IL-6 and IL-8 also occurs in other ovarian cancer cell lines, we measured IL-6 and IL-8 mRNA levels in other ovarian cancer cell lines COV504 and COV413B expressing SHMT1 shRNA and observed similar results (Figures 5b and c).