PTH and tumor of parathyroid gland: Indeed 75% of the parathyroid tumours of Cdc73+/−, Cdc73+/L/PTH-Cre and Cdc73L/L/PTH-Cre mice, when compared to wild-type littermates had features found in APAs (Table 1),1, 9 that included: increased collagen deposition in the septa (Figures 3e–h); reduced nuclear expression of parafibromin (Figures 3i–l); and increased expression of galectin-3 (Figures 3m–p).