CDC73 and tumor of uterus: These uterine neoplasms developed in ~33% of female Cdc73+/− mice (Figure 5), whilst spontaneous uterine lesions were not observed in wild-type mice in our study and are also reported to be exceedingly rare in normal wild-type mice.58 Thus, these Cdc73+/− female mice provide a model to investigate the molecular basis of uterine tumourigenesis.