The silencing of FOXO3A inhibits hypoxia-induced brain–blood barrier hyperpermeability,50 and FOXM1B activates glioma angiogenesis by promoting vascular endothelial growth factor expression.51 FOXC1 plays an oncogenic role in melanoma52 and endometrial carcinoma,53 and has been reported to regulate the function and gene expression of ECs. The gene discussed is FOXO3; the disease is central nervous system cancer.