LncRNA-RNCR3 has been implicated in atherosclerosis-related EC dysfunction by sponging miR-185-5p.28 lncRNA-MIAT is involved in diabetes mellitus-induced retinal pathological angiogenesis, and MIAT was shown to regulate the behavior of ECs that were cultured in a high-glucose medium.29 The present study provided evidence that lncRNA XIST regulates GECs function. The gene discussed is XIST; the disease is diabetes mellitus.