The latter forms a transcription complex by combining with common-mediator Smads (Co-Smads), subsequently translocating to the nucleus and completing the intracellular signal transduction process.38 In this study, we demonstrate that SMC4 promotes glioma cell aggressiveness and activates the TGFβ/Smad pathway along with Smad2/3 phosphorylation, and enhances Smad2/3 nuclear translocation. Here, SMAD2 is linked to central nervous system cancer.