SACK1A and familial pancreatic carcinoma: The FAM83A locus is located on chromosome 8q24.13, which is frequently amplified in a number of human cancers.24, 25, 26, 27 Analysis of FAM83A copy number variation (CNV) in the TCGA data set revealed the FAM83A locus was amplified in 37.3% of pancreatic cancer samples and FAM83A mRNA expression was significantly associated with FAM83A CNV (Figures 6a and c).