In agreement, FAM83A was upregulated at both the protein and mRNA levels in all ten pancreatic cancer cell lines analyzed compared with 2 primary normal human pancreatic duct epithelial cell lines, and in 10 human pancreatic cancer samples compared with the matched adjacent non-tumor tissues (Figures 1c and d and Supplementary Figures S1a and b). Here, SACK1A is linked to familial pancreatic carcinoma.