Immunohistochemical analysis confirmed FAM83A was markedly upregulated in pancreatic cancer tissues (n=103) but barely detectable in normal pancreatic tissues (n=10; Figure 1e), and FAM83A protein expression was positively associated with clinical stage (P=0.005), tumor-node-metastasis (TNM) classification (T: P=0.010; N: P=0.004; M: P=0.013) and histological differentiation (P=0.014) in pancreatic cancer (Supplementary Table S2). The gene discussed is SACK1A; the disease is familial pancreatic carcinoma.