SACK1A and familial pancreatic carcinoma: Furthermore, overexpressing FAM83A in pancreatic cancer cell lines significantly increased the proportions of SP+ cells, a sub-population of cells that can exhibit drug resistance and have CSC-like characteristics (Figure 2e).21 In agreement with this observation, FAM83A-transduced cells exhibited higher resistance to chemotherapeutic drugs such as gemcitabine and 5-FU (Figure 2f).