SMAD3 and pancreatic adenocarcinoma: Furthermore, the expression of FAM83A was strongly associated with the levels of p-Smad3 (P<0.001) and nuclear β-catenin (P<0.001; Figure 5d), indicators of TGF-β/Smad and Wnt/β-catenin pathway activation, respectively, in 103 paraffin-embedded pancreatic adenocarcinoma samples.