PDK1 and acute myeloid leukemia: Indeed, PDK1 has been shown to control growth and progression of several tumors: breast [106,107,108], prostate [109], pancreatic [99], gastric [100], colorectal [110,111]; ovarian [112], esophageal [113], gallbladder [114], acute myeloid leukemia [115] and melanoma [98,116].